Paternal inheritance of translocation chromosomes in a t(X;21) patient with X linked muscular dystrophy.
نویسندگان
چکیده
A number of DNA probes from the short arm of the X chromosome have been used to study the inheritance of the translocation chromosomes in a girl with an X; autosome translocation and muscular dystrophy. The two translocation chromosomes were found to be derived from the father's single normal X chromosome, ruling out maternal inheritance of a pre-existent mutation and enhancing the concept that the de novo translocation is responsible for the dystrophic phenotype.
منابع مشابه
Prenatal identification of a girl with a t(X;4)(p21;q35) translocation: molecular characterisation, paternal origin, and association with muscular dystrophy.
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عنوان ژورنال:
- Journal of medical genetics
دوره 23 6 شماره
صفحات -
تاریخ انتشار 1986